The latest data from the European Monitoring Center for Drugs and Drug Addiction (2018) shows that cannabinoids are the most widely used drugs in Europe by young adults aged 15 to 34, followed by cocaine, while heroin, today, is increasingly produced and consumed, a result that is also observed for behavioral addiction. From the comparison with European data, Italian data confirms the primacy of cannabis use among young adults. Considering the extent of the phenomenon and the impact on health of the youth community, the Health and Addiction Unit of the Roma 3 Local Health Authority has activated the PDTA “Diagnostic Therapeutic Assistance Path – PDTA – on Fragility related to Addiction: Minor and Young Adult patients – 13/22 years – with psychopathological and psychiatric problems related to addiction, from substance and / or behavior, and their families” with the aim to increase the range of young users aged 13 to 22 who apply to the National Health Service for diagnosis and treatment; to lower the age of entry to the Services with respect to the age of onset that, in Italy, is about 6 years and to check the methodology used towards the value of the dropout. In the first 18 months of activity, 89 patients are assigned to the diagnostic process, structured according to a precise standard methodology, of which only 8 were dropouts. It is important to underline that the data emerged from the sample belonging to the PDTA puts in an average of 3-year gap between debut and request for help to a specialist service, with a considerable decrease compared to the national average of 6 years. Reaching the young as early as possible who begin using substances means being able to start the dedicated intervention as soon as possible and potentially reduce the time of use. The service also allows for secondary preventive interventions aimed at avoiding the transition from the use of THC to other substances of abuse. The objectives set by the PDTA have been achieved and the validity and efficacy of the procedures and methodologies used are now confirmed.